Breast Cancer Epidemiology

Contents
1 Global Burden of Breast Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Jacques Ferlay, Clarisse He´ ry, Philippe Autier,and Rengaswamy Sankaranarayanan
2 Breast Cancer Biology and Clinical Characteristics . . . . . . . . . . . . . . 21
Amanda I. Phipps and Christopher I. Li
3 In situ Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Brian L. Sprague and Amy Trentham-Dietz
4 Endogenous Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Amanda I. Phipps and Christopher I. Li
5 Exogenous Hormones. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89
Christopher I. Li and Elisabeth F. Beaber
6 Reproductive Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Mats Lambe
7 Physical Activity and Anthropometric Factors . . . . . . . . . . . . . . . . . . 137
Katherine D. Henderson, Jennifer Prescott,and Leslie Bernstein
8 Diet and Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Martin Lajous and Shumin M. Zhang
9 Environmental and Occupational Exposures . . . . . . . . . . . . . . . . . . . 183
Amanda I. Phipps, Dana Mirick, Christopher I. Li,and Scott Davis
10 Shift Work and Circadian Disruption. . . . . . . . . . . . . . . . . . . . . . . . . 223
Scott Davis and Dana K. Mirick
11 Non-Hormonal Medications and Chronic Diseases . . . . . . . . . . . . . . 243
Patricia F. Coogan
12 Male Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Ian S. Fentiman
13 Inherited Predisposition: Familial Aggregation and HighRisk
Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 277
Kathleen E. Malone and Kerryn W. Reding
14 Common Genetic Susceptibility Loci . . . . . . . . . . . . . . . . . . . . . . . . . 301
Mikkel Z. Oestergaard and Paul Pharoah
15 Mammographic Density as a Potential Surrogate Markerfor Breast
Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 321
Norman F. Boyd, Lisa J. Martin, and Salomon Minkin
16 Breast Cancer Screening . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343
Karla Kerlikowske
17 Principles of Breast Cancer Therapy . . . . . . . . . . . . . . . . . . . . . . . . . 371
Allison W. Kurian and Robert W. Carlson
18 Breast Cancer Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
Graham A. Colditz and Courtney Beers
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 403

Product Description

Breast cancer remains a disease of considerable public health
importance worldwide, with over 800,000 new cases diagnosed globally
each year. Considerable energy is currently being spent by researchers
to further our understanding of this complex disease, however, keeping
up with all of the new data is a real challenge given the sheer volume
of information that becomes available on a daily basis. The purpose of
this book would be to provide a comprehensive review of breast cancer
epidemiology, covering the topics of disease burden, etiology, risk
factors, prevention, early detection/screening, treatment, and outcomes.
The book would be a single comprehensive source of the most recent
information on breast cancer epidemiology, and it would serve as a
valuable resource for breast cancer researchers across disciplines
regardless of what stage of their career they are in. To the knowledge
of the editor, no such resource is currently available.

From the Back Cover
As the most common cancer diagnosed among women world-wide, breast
cancer is a disease of considerable public health importance. The number
of established and hypothesized risk factors for breast cancer exceeds
that of any other cancer resulting in a rich, but complicated and often
conflicting literature on the epidemiology of this disease. Our
understanding of factors that contribute to breast cancer risk, as well
as the biology and molecular basis for this common disease, has greatly
increased over the past few decades. This book provides a comprehensive
review and critical assessment of the epidemiology literature on all
major aspects of breast cancer incidence and mortality, etiology, and
outcomes. Chapters are written by internationally recognized leaders in
the field and provide a timely review of traditional etiologic risk
factors, as well as more recently evaluated exposures. Several chapters
are also devoted to clinical aspects of breast cancer including
screening, diagnosis and treatment, and survival. As a result, this is
the most up-to-date and comprehensive book on breast cancer epidemiology
available.





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