Platinum-Based Drugs in Cancer Therapy
The Institute of Cancer Research, UK. Review of all aspects of platinum anticancer drugs and their current use in treatment, as well as future
therapeutic prospects. Includes DNA mismatch repair, replicative bypass,
apoptosis, and the transport of platinum drugs into tumor cells. For
students, researchers, and clinicians.
This volume of the Cancer Drug Discovery and Development series provides comprehensive coverage of some of the basic
science associated with cisplatin, its interaction with DNA and how
recognitions and processing of platinum-DNA adducts may be associated
with tumour response or resistance. …Bringing together the most recent
research in the area of platinum drugs…The editors of this book have
produced a collection of articles which will be of interest to those who
need an introduction to the field of platinum drugs. For anyone already
familiar with the field, the chapters on the newer analogues and on
some of the more recent basic molecular pharmacology issues will provide
a useful update. -The Lancet “The great attention is also paid to all
toxicological aspects of platinum drugs from both clinical and regulatory perspective…. The Platinum-based Drugs in Cancer Therapy appears to be a
comprehensive book useful for scientist, medical oncologist and pharmacist seeking answer on specific questions concerning preclinical and clinical data of platinum drugs.
Review This volume of the Cancer Drug Discovery and Development series
provides comprehensive coverage of some of the basic science associated
with cisplatin, its interaction with DNA and how recognitions and
processing of platinum-DNA adducts may be associated with tumour
response or resistance. ...Bringing together the most recent research in
the area of platinum drugs...The editors of this book have produced a
collection of articles which will be of interest to those who need an
introduction to the field of platinum drugs. For anyone already familiar
with the field, the chapters on the newer analogues and on some of the
more recent basic molecular pharmacology issues will provide a useful
update. -The Lancet
"The great attention is also paid to all
toxicological aspects of platinum drugs from both clinical and
regulatory perspective.... The Platinum-based Drugs in Cancer Therapy
appears to be a comprehensive book useful for scientist, medical
oncologist and pharmacist seeking answer on specific questions
concerning preclinical and clinical data of platinum drugs."-Neoplasma
"The strength of the text lies in the diversity of topics that are
covered in such a succinct fashion. Clinicians will benefit from the
earlier focus on basic chemistry and biochemistry, while the bench
scientist will better appreciate the practicalities of using these
compounds from the lucid experiences of the clinical case
studies."-Journal of Medicinal Chemistry
"This is a useful
reference book for scientists and practitioners who have a focus or
interest in the chemistry and biochemistry of the platinum compounds.
Oncologists will find it helpful for its summary of applications of
cisplatin and carboplatin, especially in combination with
paclitaxel."--Oncology Journal, November, 2000
"...the book
should find its place in the library of many laboratories involved
mainly in preclinical oncological research."-Annals of Oncology
"This new book by Kelland and Farrell is a well-constructed and
authoritative account of current knowledge concerning the pharmacology
and clinical application of platinum anticancer drugs. It is well
illustrated with clear diagrams and appropriate data. ...Not only do
platinum agents remain a key component of current cancer therapy for the
majority of common solid tumours but recent advances have demonstrated
the scope for expansion of the clinical spectrum of activity, the
ability to overcome resistance, and the potential introduction of oral
delivery." - Clinical Oncology
Product Description Leading international experts comprehensively review all aspects of
platinum anticancer drugs and their current use in treatment, as well as
examining their future therapeutic prospects. Writing from a variety of
disciplines, these authorities discuss the chemistry of cisplatin in
aqueous solution, the molecular interaction of platinum drugs with DNA,
and such exciting new areas as DNA mismatch repair and replicative
bypass, apoptosis, and the transport of platinum drugs into tumor cells.
The emergent platinum drugs of the future-orally active agents, the
sterically hindered ZD0473, and the polynuclear charged platinum
BBR3464-are also fully considered. Timely and interdisciplinary,
Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics
specialists an illuminating survey of every aspect of platinum drugs
from mechanisms of action to toxicology, tumor resistance, and new
analogs.
Product Details
- Paperback: 360 pages
- Publisher: Humana Press; Softcover reprint of hardcover 1st ed. 2000 edition (December 8, 2010)
- Language: English
- ISBN-10: 1617370916
- ISBN-13: 978-1617370915
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