Leukemia: Methods and Protocols


Recent advances in molecular and cellular biology techniques have
significantly improved our ability to detect, monitor, model and study
the underlying molecular basis and pathogenesis of leukemia, yet we are
still in an early discovery stage and much more work is needed in order
to develop better strategies to diagnose, classify and treat this
biologically and clinically diverse disease. In Leukemia: Methods and Protocols,
expert researchers bring together a wide range of state-of-the-art
laboratory methods and detailed protocols that are useful for both
clinical and basic research scientists working on the disease. The
volume provides techniques for prenatal backtracking of leukemic clone,
molecular diagnosis, detection of genome-wide genetic abnormalities and
profiling, identification of unknown fusion genes, monitoring of minimal
residual diseases, disease modeling using murine and human primary
hematopoietic cells, studying of normal and malignant hematopoiesis,
identification of interacting partners with leukemia associated
oncoproteins, and global characterization of genome-wide epigenetic
changes in leukemic cells. Written in the highly successful Methods in Molecular Biology™
series format, the convenient chapters contain brief introductions,
lists of the necessary materials, step-by-step, readily reproducible
protocols, and notes on troubleshooting and avoiding
known pitfalls.
Comprehensive and cutting-edge, Leukemia: Methods and Protocols will help researchers to advance knowledge and have a better understanding of the disease, which will ultimately facilitate development of anti-cancer therapy and improve quality of life for patients.

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