The Heart in Systemic Autoimmune Diseases
This first volume represents the state-of-the-art in the field of
cardiovascular disease and autoimmune rheumatic diseases. Systemic
autoimmune diseases comprise a family of conditions that share common
pathogenetic mechanisms as well as a multi-organ involvement including
the heart. This volume has been subdivided into three parts. In the
first part, the immune mechanisms involved in cardiac damage have been
considered. The role of proinflammatory and regulatory cytokines in
driving an autoimmune response to cardiac self-tissues has been
analysed. Moreover, the prevalence, the clinical meaning and the
hypothetical pathogenicity of a broad spectrum of organ and non-organ
specific autoantibodies have been discussed in detail. In the second
part of the volume, the role of humoral and innate immunity in promoting
the development of atherosclerotic plaque has been extensively
reviewed, along with the newly discovered anti-inflammatory properties
of statins. These two parts of the volume deal with exciting aspects of
this topic, suggesting a very close connection between heart diseases
and immunology. Finally, in the third part, the cardiac manifestations
observed in the major systemic autoimmune conditions have been
comprehensively examined.
This book yields an impressive body of well ordered information,
highlighting key references and summarising the experience of a selected
panel of distinguished physician-scientists actively involved in the
field of cardiovascular disease and systemic autoimmunity

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