Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management

This
book is a completely revised new edition of the definitive reference on
disorders of hemoglobin. Authored by world-renowned experts, the book
focuses on basic science aspects and clinical features of
hemoglobinopathies, covering diagnosis, treatment, and future
applications of current research. While the second edition continues to
address the important molecular, cellular, and genetic components,
coverage of clinical issues has been significantly expanded, and there
is more practical emphasis on diagnosis and management throughout. The
book opens with a review of the scientific underpinnings.
Pathophysiology of common hemoglobin disorders is discussed next in an
entirely new section devoted to vascular biology, the erythrocyte
membrane, nitric oxide biology, and hemolysis. Four sections deal with ?
and ? thalassemia, sickle cell disease, and related conditions,
followed by special topics. The second edition concludes with current
and developing approaches to treatment, incorporating new agents for
iron chelation, methods to induce fetal hemoglobin production, novel
treatment approaches, stem cell transplantation, and progress in gene
therapy

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