Cardiorenal Syndrome: Mechanisms, Risk and Treatment Hardcover
by Adel E. Berbari (Editor), Giuseppe Mancia (Editor)

Chronic kidney disease with Cardiorenal a worldwide prevalence of 10% in the general population is becoming a public health priority .Cardiorenal Renal dysfunction is associated with a high risk of cardiovascular complications.Cardiorenal There is a relationship between renal failure and cardiovascular disease called cardio renal syndrome if the function is a consequence of the infringement of primary renal parenchymal or primary heart disease.

Cardiorenal They have proposed several pathophysiological mechanisms to explain the relationship between renal dysfunction and cardiovascular disease.Cardiorenal Recent studies indicate an integrated response of vascular smooth muscle and glomerular mesangial cells to traditional and uremia factors of cardiovascular risk.Cardiorenal The traditional risk factors can lead to kidney failure and heart damage.

Cardiorenal As renal function declines ,Cardiorenal the risk factors associated with uremia - play an increasing role in the reduction of glomerular filtration rate and cardiovascular damage. Several related factors such as vascular uremia uncontrolled hypertension disturbed metabolism of glucose insulin , microalbuminuria , phosphate retention ,Cardiorenal secondary hyperparathyroidism , calcification infarction and hypertensive cardiomyopathy uremic inflammation , oxidative injury , and neurohormonal dysregulation has been implicated in the pathogenesis of cardiovascular renal syndrome. Recent data suggest that treatment of cardiovascular syndrome requires aggressive control of traditional risk factors and new approaches to preventing or reversing the processes associated with uremia.

Cardiorenal This book presents an analysis of the complete renovation of our current understanding of Cardiorenal  , including epidemiology , pathophysiology, and therapeutic approaches
Review
From the reviews:
“The first book to bring together information on this important and recently named entity, cardiorenal syndrome. … Nephrologists, cardiologists, and trainees in both specialties can benefit from the information presented in this book … . The book presents a novel concept regarding the structural and functional similarities between vascular smooth muscle cells and glomerular mesangial cells. … This is an important contribution since it is the first one to comprehensively address this frontier between nephrology and cardiology.” (Mony Fraer, Doody’s Review Service, April, 2011)

From the Back Cover
Accelerated cardiovascular disease is a frequent complication of chronic kidney disease. Individuals with evidence of renal functional impairment are more likely to die of cardiovascular events than to progress to end stage renal disease.
This relationship, which has been termed the cardiorenal syndrome, exists whether impairment of renal function is a consequence of primary renal parenchymal or primary heart disease.
The mechanisms underlying the cardiorenal syndrome result from a complex interaction of traditional and uremia related cardiovascular risk factors. Prevention and management of cardiovascular disease include aggressive control of traditional risk factors as well novel approach to prevent or reverse uremia related processes.
Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease.
This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome, including epidemiology,  pathophysiologic mechanisms, and therapeutic approaches.


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