Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification


Learn the core concepts and step-by-step methods for assessing cancer risk
With its focus on quantitative methods and weight of the evidence,
Cancer Risk Assessment enables readers to accurately assess human cancer
risk from exposure to chemical agents, including solvents, metals,
mixtures, and nanoparticles. Moreover, the book helps readers understand
the link between cancer risk and the basic toxicology and biology of
cancer.
Each chapter of this contributed work has been written by one or more
leading international experts. Their contributions integrate a
comprehensive review of the scientific literature with their own
personal hands-on experience as well as their knowledge of current
regulations and testing guidelines. With the authors’ guidance, readers
can better analyze toxicological data in order to reduce the
uncertainties in chemical-related cancer evaluations and risk
assessments.
The book begins with an overview of cancer risk assessment, science
policy, and the regulatory framework for industrial chemicals and
biocides. Next, all the core concepts, skills, and methods needed to
perform cancer risk assessments are covered in detail, including:
* Key fundamentals in cancer biology, chemical carcinogenesis,
hormesis, and experimental evidence of thresholds for genotoxic
carcinogens
* Testing guidelines and regulations for in vitro and in vivo genotoxicity testing
* Evaluation of toxicological data and its relevance to hazard evaluation and cancer risk estimation
* Methods for quantifying cancer risk, including quantitative
structure-activity relationships, physiologically-based pharmacokinetic
modeling, “-omics,” and computational toxicology
Readers of Cancer Risk Assessment not only learn to perform
state-of-the-science cancer risk assessments, but also gain valuable
skills and knowledge in the more general fields of toxicology and risk
assessment

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