The Heart in Systemic Autoimmune Diseases

This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms
as well as a multi-organ involvement including the heart. This volume
has been subdivided into three parts. In the first part, the immune mechanisms
involved in cardiac damage have been considered. The role of
proinflammatory and regulatory cytokines in driving an autoimmune
response to cardiac self-tissues has been analysed. Moreover, the
prevalence, the clinical meaning and the hypothetical pathogenicity of a
broad spectrum of organ and non-organ specific autoantibodies have been
discussed in detail. In the second part of the volume, the role of
humoral and innate immunity in promoting the development of
atherosclerotic plaque has been extensively reviewed, along with the
newly discovered anti-inflammatory
properties of statins. These two parts of the volume deal with exciting
aspects of this topic, suggesting a very close connection between heart
diseases and immunology. Finally, in the third part, the cardiac
manifestations observed in the major systemic autoimmune conditions have
been comprehensively examined.
This book yields an impressive body of well ordered information,
highlighting key references and summarising the experience of a selected
panel of distinguished physician-scientists actively involved in the
field of cardiovascular disease and systemic autoimmunity.
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